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SC-32750

器件型号:SC-32750
文件大小:779.11KB,共1页
厂商名称:SCBT
厂商官网:http://www.scbt.com/
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cd223

SC-32750器件文档内容

SANTA CRUZ BIOTECHNOLOGY, INC.

CD223 (C9B7W): sc-32750

                                                                                 The Power to Question

BACKGROUND                                                                       APPLICATIONS
                                                                                 CD223 (C9B7W) is recommended for detection of CD223 of mouse origin by
CD223 (Lymphocyte activation gene-3, LAG-3) is a high affinity MHC class II      flow cytometry (1 g per 1 x 106 cells).
ligand present on the surface of CD4+/CD8+ T cells and NK cells. CD223           Suitable for use as control antibody for CD223 siRNA (m): sc-44548.
shares homology in structure to CD4 molecules, having four similar extracel-     Molecular Weight of CD223: 70 kDa.
lular Ig-like domains and structural motifs between D1-D3 and D2-D4
domains. CD223 has a glutamic acid-proline (EP) repetitive sequence found        DATA
in other functionally distinct mammalian, parasitic, and bacterial proteins
that may influence a conserved biological function. CD223+/CD4+/CD8+ T
cells can associate with the T cell receptor (TCR) and downregulate TCR sig-
naling in vitro. CD223 inhibits CD4-dependent T cell function via its cytoplas-
mic domain . CD223 Lys-468 within a conserved "KIEELE" motif is essential
for interaction with downstream signaling molecules.

REFERENCES                                                                       CD223 (C9B7W) PE: sc-32750 PE. FCM analysis of
                                                                                 CTLL-2 cells. Black line histogram represents the iso-
1. Demeure, C.E., et al. 2001. T Lymphocytes infiltrating various tumour         type control, normal rat IgG1: sc-2871.
  types express the MHC class II ligand lymphocyte activation gene-3 (LAG-
  3): role of LAG-3/MHC class II interactions in cell-cell contacts. Eur. J.     STORAGE
  Cancer 37: 1709-1718.                                                          Store at 4 C, **DO NOT FREEZE**. Stable for one year from the date of
                                                                                 shipment. Non-hazardous. No MSDS required.
2. Online Mendelian Inheritance in Man, OMIMTM. 2002. Johns Hopkins
  University, Baltimore, MD. MIM Number: 153337. World Wide Web URL:             RESEARCH USE
  http://www.ncbi.nlm.nih.gov/omim/                                              For research use only, not for use in diagnostic procedures.

3. LocusLink Report (LocusID: 3902). http://www.ncbi.nlm.nih.gov/LocusLink/      PROTOCOLS
                                                                                 See our web site at www.scbt.com or our catalog for detailed protocols
4. Andreae, S., et al. 2002. Maturation and activation of dendritic cells        and support products.
  induced by lymphocyte activation gene-3 (CD223). J. Immunol. 168:
  3874-3880.

5. Workman, C.J., et al. 2002. Phenotypic analysis of the murine CD4-related
  glycoprotein, CD223 (LAG-3). Eur. J. Immunol. 32: 2255-2263.

6. Workman, C.J., et al. 2002. Cutting edge: molecular analysis of the nega-
  tive regulatory function of lymphocyte activation gene-3. J. Immunol. 169:
  5392-5395.

7. Buisson, S., et al. 2003. MHC class II engagement by its ligand LAG-3
  (CD223) leads to a distinct pattern of chemokine and chemokine receptor
  expression by human dendritic cells. Vaccine 21: 862-868.

CHROMOSOMAL LOCATION
Genetic locus: LAG3 (human) mapping to 12p13.3; LAG3 (mouse) mapping to 6.

SOURCE
CD223 (C9B7W) is a rat monoclonal antibody raised against a fusion protein
consisting of the entire extracellular region of mouse CD223 with mouse
IgG1 and recognizes an epitope in the D2 domain of CD223.

PRODUCT
Each vial contains 200 g IgG1 in 1.0 ml of PBS with < 0.1% sodium azide
and 0.1% gelatin.

Available as phycoerythrin (sc-32750 PE) or fluorescein (sc-32750 FITC)
conjugates for flow cytometry, 100 tests.

Santa Cruz Biotechnology, Inc. 1.800.457.3801 831.457.3800 fax 831.457.3801 Europe +00800 4573 8000 49 6221 4503 0 www.scbt.com
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